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RESEARCH ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 67-72

Synthesis and cytotoxicity assessment of 2-(4-fluorophenyl)-N-halophenylacetamide derivatives as anticancer agents


1 Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Alireza Aliabadi
Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah
Iran
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Source of Support: None, Conflict of Interest: None


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Cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. Because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. In the present study we synthesized new derivatives of 2-(4-Fluorophenyl)-N-halophenylacetamide and assessed their cytotoxicity against five cancerous cell lines consisted of PC3 (Prostate cancer), Hela (Cervical cancer), ACHN (Renal cell carcinoma), MCF-7 (Breast cancer) and HL-60 (Promyelocytic leukemia). All compounds demonstrated better cytotoxic activity towards PC3 cell line compared to other cell lines. Compound 2b showed the best cytotoxic effect in this series (IC50 = 102 μM/L). Replacement of butyl chain with phenyl ring led to the increase and improvement of the cytotoxic effects.


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