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RESEARCH ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 165-170

Chemical composition and general toxicity of essential oil extracted from the stalks and flowers of Rheum Ribes L. growing in Iran


1 Novel Drug Delivery Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran
2 Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, I.R. Iran
3 Medical Philosophy and History Research Center and Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, I.R. Iran

Correspondence Address:
Fariba Heshmati Afshar
Medical Philosophy and History Research Center and Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz
I.R. Iran
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Source of Support: None, Conflict of Interest: None


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The essential oil of Rheum ribes L. stalks and flowers, growing in Iran, were extracted with hydro-distillation and analyzed by GC-MS. Thirty constituents representing 93.84% of Rheum oil were identified. The oil was found to be rich in hydrocarbons especially long-chain n-alkanes (80.81%). The most abundant components in the oil included tricosane (26.29%), heneicosane (26.07%), pentacosane (10.63%), heptacosane (10.37%) and palmitic acid (3.64%). The essential oil was also evaluated for general toxicity bioassay using brine shrimp lethality method. The toxicity profile of the oil indicated some degree of toxicity in comparison with podophyllotoxin.


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