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RESEARCH ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 179-189

Simultaneous spectrophotometric determination of amlodipine and metoprolol by principal component regression multivariate calibration and comparison with HPLC


1 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical sciences, Isfahan University of Medical Sciences, 81746-73461 Isfahan, Iran
3 Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical sciences, Isfahan University of Medical Sciences, 81746-73461 Isfahan, Iran

Correspondence Address:
Lotfollah Saghaie
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical sciences, Isfahan University of Medical Sciences, 81746-73461 Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


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Multi-drug therapy in high blood pressure is appreciated to achieve a normal blood pressure. A simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (Amd) and metoprolol (Met) in pharmaceutical preparations. Calibration matrix contains 3.402 μgml-1 to 170.130 μg ml-1 amlodipine and 13.7 μg ml-1 to 68.5 μgml-1 metoprolol. The proposed method was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneous determination of amlodipine and metoprolol in different pharmaceutical preparations.


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