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RESEARCH ARTICLE
Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 54-64

Formulation and evaluation of orally disintegrating tablets of captopril using natural super disintegrants


1 Department of Pharmaceutics, School of pharmacy and pharmaceutical Sciences. Isfahan University of medical Science, Isfahan, Iran
2 Student of pharmacy, Department of Pharmaceutics, school of pharmacy and pharmaceutical sciences, Isfahan University of medical Science, Isfahan, Iran

Correspondence Address:
Mohammad Ali Shahtalebi
Department of Pharmaceutics, School of pharmacy and pharmaceutical Sciences. Isfahan University of medical Science, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


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Difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and children. Orally Disintegrating tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quicksetof action. The purpose of this study was to formulate and evaluate an orally Disintegrating Tablet (ODT) containing captopril while using croscarmellose sodium, crospovidone and two natural superdisintegrants: karaya gum and natural agar. For the preliminary study 12 batches were prepared. A 32 full factorial design was applied to optimize the formulation and 9 batches were prepared and evaluated. From the preliminary study it was found that ODTs containing karaya gum showed a better disintegration time and hence it was considered for further studies. According to the Results of optimized batches, the best concentration of superdisintegrant and binder were obtained. Karaya gum in the concentration of 9% w/w with Avicel PH 102 in25% w/w gave rapid disintegration in 25sec and showed 100% drug release within 5 minuteso it was concluded that orally disintegrating tablets of captopril can be successfully formulated using karaya gum.


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