• Users Online: 1
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
RESEARCH ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 12-23

Analytical utility of potassium permanganate for the assay of albendazole in bulk drug and pharmaceuticals


Department of Studies in Chemistry, Manasagangothri, University of Mysore-570 006, India

Correspondence Address:
Kanakapura Basavaiah
Department of Studies in Chemistry, Manasagangothri, University of Mysore-570 006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Two rapid, simple, sensitive and cost-effective titrimetric and spectrophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in pharmaceuticals. In titrimetry (method A), ALB is oxidized by a known excess of potassium permanganate (KMnO4) in H2SO4 medium followed by the determination of unreacted permanganate by titration with ferrous ammonium sulphate (FAS). In spectrophotometry (method B), ALB is treated with a measured excess of permanganate in acid medium and the unreacted oxidant is measured at 545 nm. The molar ratio (stoichiometry) in titrimetry and the optimum assay conditions are studied. Titrimetry is applicable over 2-9 mg range and the calculations are based on a 1:1 (ALB: KMnO4) molar-ratio. In spectrophotometry, Beers law is obeyed over 8.0-64.0 μg mL-1 concentration range of ALB. The molar absorptivity and Sandell sensitivity values are calculated to be 3.348 × 103 L mol-1 cm-1 and 0.08 μg cm-2, respectively. The limits of detection (LOD) and quantification (LOQ) are also reported for the spectrophotometric method. The applicability of the developed methods is demonstrated by the assay of ALB in pure drug as well as in commercial formulations.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed325    
    Printed55    
    Emailed0    
    PDF Downloaded82    
    Comments [Add]    

Recommend this journal