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RESEARCH ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 2  |  Page : 135-142

The effects of essential oil of Lavandula Angustifolia on sperm parameters quality and reproductive hormones in rats exposed to cadmium


1 Young Researchers and Elite Club, Hamedan Branch, Islamic Azad University, Hamedan, Iran
2 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Anatomy, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
4 Department of Clinical Sciences, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Karaj, Iran
5 Department of Pharmacology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
6 Proteomics Research Center, and Department of Medical Laboratory Technology, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Correspondence Address:
Nayeb Ali Ahmadi
Proteomics Research Center, and Department of Medical Laboratory Technology, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


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Male infertility evaluation is important to recognize an origin and provide treatment if the etiology is correctable. The aim of the present study was to investigate the protective role of Lavandula angustifolia in impaired spermatogenesis caused by cadmium chloride in male rats. 36 male Wistar rats were allocated in 6 groups. Cadmium chloride was injected for 3 consecutive days (0.5 mg/kg) in CdCl2 treated groups. Before CdCl2 administration, pre-treatment with L. angustifolia was conducted for 14 consecutive days. Sex hormones level, malondialdehyde (MDA) and total antioxidant concentration as well as sperm parameters were investigated. Increase in the concentration of MDA and decrease in total antioxidant level were observed following CdCl2 administration. Accordingly, the sperm viability as well as other sperm characteristics was decreased. In the case of sex hormones, the testosterone and LH levels were decreased and the concentration of FSH was increased (P<0.001). Pre-treatment with L. angustifolia significantly decreased the MDA level and increased total antioxidant, LH and testosterone levels. Pre-treatment with L. angustifolia also improved semen parameters which were impaired by CdCl2 administration. Together, these results confirm that L. angustifolia pretreatment could protect spermatogenesis in male rats with CdCl2 administration.


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