• Users Online: 321
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
RESEARCH ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 2  |  Page : 143-154

Assay of pyrantel pamoate using iron (III) chloride and three complexing agents by spectrophotometry


Department of Chemistry, Manasagangothri, University of Mysore-570 006, India

Correspondence Address:
Kanakapura Basavaiah
Department of Chemistry, Manasagangothri, University of Mysore-570 006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Three rapid, simple, moderately sensitive and selective spectropho-tometric methods are described for the determination of pyrantel pamoate (PYP) in bulk drug and in its pharmaceutical formulations. The methods are based on the reduction of ferric chloride by PYP in neutral medium and subsequent complexation of iron (II) with ferricyanide (method A), 1, 10-phenanthroline (method B) and 2, 2'-bipyridyl (method C). The absorbances of resulting colored products were measured at 750, 520 and 530 nm, respectively. Under the optimum conditions, Beer's law enabled the determination of the drug in the concentration ranges 3.0-35, 1.0-30 and 2.0-35 μg mL-1 with apparent molar absorptivities of 1.38 × 104, 2.06 × 104 and 1.23 × 104 L mol-1 cm-1 for method A, method B and method C, respectively. The Sandell sensitivity values, limits of detection (LOD) and quantification (LOQ) values have also been reported for all methods. The accuracy and precision of the methods were evaluated on intra-day and inter-day basis; the relative error (%RE) was ≤ 3.0 % and the relative standard deviation (RSD) was ≤ 1.98 %. The developed methods were successfully applied to the determination of drug in tablets and suspension without interference by the common excipients.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed314    
    Printed41    
    Emailed0    
    PDF Downloaded84    
    Comments [Add]    

Recommend this journal