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RESEARCH ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 1  |  Page : 1-11

Formulation and evaluation of co-amoxiclav 228 and 312 mg dispersible tablets


Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Abolfazl Aslani
Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


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Dispersible tablet is a new form of tablet which any dose of it is dispersed in a small amount of water to create a uniform suspension. The advantage of this formulation is its better and faster effect, no need to swallow, more stability compared to suspension, better taste and greater acceptance by the patients especially kids and elders. This study aimed to design and formulize dispersible tablets including Co- Amoxiclav 228 and 312 mg for enhancement of stability and easier usage and consumption. Co amoxiclav dispersible pill was made by dry granulation method using superdisintegrants ingredients such as crospovidone, croscarmellose sodium and sodium starch glycolate and effervescent materials such as citric acid and sodium bicarbonate. The mixed powder was tested in terms of compressibility, particle size distribution and powders flowability. Some tests were performed for determination of assay, content uniformity, hardness and friability of tablet, weight variation, wetting time, water absorption ratio and disintegration of tablets. Prepared granules had good flowability, compressibility and the hardness and friaibility of tablets were in an acceptable range in most formulations. Formulations made by effervescent bases E3 and E4 had disintegration time of 25 and 35 seconds and S1, S4 and S5 formulations made from superdisintegrants materials showed the disintegration time of 260, 262 and 275 seconds. E4 formulation containing amoxicillin trihydrate, potassium clavulanate, citric acid, sodium bicarbonate, manitol, aspartame and PEG 6000 had 25 sec disintegration time and 40 N hardness.


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