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RESEARCH ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 1  |  Page : 53-60

Effects of migriheal® on plasma proteome of patients with migraine headaches


1 Biochemistry Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran

Correspondence Address:
Mohammad Ansari
Biochemistry Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran
Iran
Mostafa Rezaei Tavirani
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


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Recently, based on herbal medicine of Iran, an herbal drug with medical effects named MigriHeal®, has been registered; it helps in prevention of migraine headache strokes. In this study, MigriHeal was administered for pure migraine patients and the aim of this study is proteomic analysis of plasma from patients with migraine headaches before and after treatment with MigriHeal®. Before and after administration of MigriHeal®, patient's plasma was obtained, and then 2DE (2-dimensional electrophoresis) proteomic analysis of 11 patients was done. The Progenesis Same Spots ver.4 software was used for statistical analysis of the gels; according to ANOVA test analysis, we showed that the expression of two proteins named alpha-2-HS-glycoprotein (p-value: 0.023) and alpha-1-B-glycoprotein (p-value: 0.008) was decreased. Two identified proteins have anti-inflammatory effects and based on this finding we concluded inflammation is a pathologic mechanism of migraine, presumably, MigriHeal® has anti-inflammatory effects. Although these are not specific for the migraine and are altered in other diseases, these two proteins may be migraine biomarkers if measured simultaneously with quantitative methods in an expanded population.


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