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REVIEW ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 2  |  Page : 94-103

Poly (lactic-co-glycolic) acid (PLGA)-based compounds for articular cartilage regeneration


Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, 8174613441, Iran

Correspondence Address:
Mehdi Mehdikhani-Nahrkhalaji
Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, 8174613441
Iran
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Source of Support: None, Conflict of Interest: None


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The most famous artificial polymers for cartilage regeneration constructs are poly lactic acid (PLA, which is present in both L and D forms), poly-glycolic acid (PGA), and their copolymer poly-lactic-co-glycolic acid (PLGA). PLGA shows high biocompatibility, a potential to break down into safe monomer units, a beneficial range of mechanical characteristics, and governable degradation time depending on the copolymer ratio. In this review we critically focused on PLGA applications such as scaffolds and carriers for bioactive agents such as drugs, growth factors, and other bioactive molecules in order to safely delivering to cartilage tissue for reconstructing articular cartilage (AC) defects


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