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RESEARCH ARTICLE
Year : 2017  |  Volume : 6  |  Issue : 1  |  Page : 34-50

Neuroprotective effects of medicinal plants and their constituents on different induced neurotoxicity methods: A review


1 Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad; Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran

Correspondence Address:
Mohammad Reza Khazdair
Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad; Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft
Iran
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Source of Support: None, Conflict of Interest: None


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In the traditional medicine, numerous plants have been used to treat cognitive disorders. Natural products play an essential role in prevention and therapy of various neurodegenerative diseases, and neuronal dysfunctions. Different studies suggest that natural products, such as polyphenolic and alkaloids compounds that isolated from plants potentially delayed the neurodegeneration and also improve memory and cognitive function. Ethno pharmacological studies have provided information to identify potential new drugs from plant sources. Recently many drugs which available in medicine were originally isolated from plants or their constituents including, anticholinesterase (Anti-ChE) alkaloids isolated from plants have been investigated for their potential in the treatment of Alzheimer's disease (AD). Anti-inflammatory and antioxidant activities of plants and isolated components form plants were used in improvement neuro-inflammation, anxiety, convulsion and etc. Medicinal plants have beneficial properties due to presence of various complex chemical substances for treatment of toxicity in the nervous system. This review article evaluated the some of the medicinal plants and their active constituents that have been used in different methods induced neurotoxicity.


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