• Users Online: 38
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
RESEARCH ARTICLE
Year : 2017  |  Volume : 6  |  Issue : 2  |  Page : 150-160

Mucoadhesive electrospun nanofibers of chitosan/gelatin containing vancomycin as a delivery system


1 Pharmaceutical Science Research Center, Faculty of Pharmacy, Kermanshah University of Medical Science, Kermanshah, Iran
2 Nano Drug Delivery Research Center, Kermanshah University of Medical Science, Kermanshah, Iran
3 Student Research Committee, Kermanshah University of Medical Science, Kermanshah, Iran

Correspondence Address:
Elham Arkan
Nano Drug Delivery Research Center, Kermanshah University of Medical Science, Kermanshah
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Mucoadhesive oral delivery systems have been of interest to researchers because of improving bioavailability and patient compliance by increasing concentration gradient. This study aimed to investigate local delivery of vancomycin using against gram-positive bacteria. Vancomycin is not absorbed from the gastrointestinal tract, so it will be given by injection. Also, slow infusion of vancomycin in blood is so vital to reduce its severe side effects and is excreted through the urine. Controlled dose of vancomycin can reduce drug resistance. Here in, a blend of chitosan and gelatin loaded with vancomycin was electrospun. The obtained nanofibers were characterized by FTIR, UV and SEM. The swelling and stability of the nanofibers were evaluated. In vitro release of the vancomycin was measured over a 72-hours period by total immersion method. The average diameter of drug-loaded nanofiber was 384 nm. The release behavior of the optimum fibrous mat conform Higuchi kinetic model.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed269    
    Printed30    
    Emailed0    
    PDF Downloaded70    
    Comments [Add]    

Recommend this journal