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RESEARCH ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 1  |  Page : 44-63

Synthesis of novel amide containing schiffs bases of 5-(4-chloro-phenyl)-furan-2-carboxaldehyde: Their In Vivo anti-inflammatory, antioxidant and antinociceptive activities with ulcerogenic risk evaluation


1 Department of Chemistry, Faculty of Science, Jamia Hamdard (Hamdard University) New Delhi -110 062, India
2 Department of Toxicology, Faculty of Science, Jamia Hamdard(Hamdard University), New Delhi -110062, India
3 Department of Pharmaceutical Chemistry, Sikkim Central University, Sikkim-737136, India

Correspondence Address:
Mohammad Sarwar Alam
Department of Chemistry, Faculty of Science, Jamia Hamdard (Hamdard University) New Delhi -110 062
India
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Source of Support: None, Conflict of Interest: None


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A library of eighteen amide containing Schiffs bases has been synthesized and screened for their anti-inflammatory, antioxidant and antinociceptive activities. The compound 2 (COX-1 IC50 = 63.23 μM; COX-2 IC50 = 1.80 μM; SI = 35.12) exhibited potent selective COX-2 inhibition as compared to indomethacin (COX-1 IC50 = 3.60 μM; COX-2 IC50 = 7.50 μM; SI = 0.48). The compounds 2 and 7 reduced the COX-2 level to 7.5 ±0.35 nmole/min/ml and 6.8 ± 0.32nmole/min/ml respectively. The compounds 6 exhibited reduced the TNF-α level to 3.36 ± 0.18pg/ml. The compounds 2, 6, 7, 13 and 17 did not induce any gastric ulceration in comparison to the standard drug indomethacin.


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