Journal of Reports in Pharmaceutical Sciences

RESEARCH ARTICLE
Year
: 2017  |  Volume : 6  |  Issue : 1  |  Page : 68--76

Comparison of the effects of adding of ketamine to pre-incisional bupivacaine injection on postoperative pain relief after tonsillectomy in children


Mansour Choubsaz1, Gholamreza Mohseni2, Sara Jorair-Ahmadi1, Masoud Sadeghi3 
1 Department of Anesthesiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Masoud Sadeghi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah
Iran

Pain control in children is still a therapeutic dilemma and preschool patients are affected from undesirable effects of postoperative pain more than adults. The aim of this work was to compare the effects of adding of Ketamine to pre-incisional Bupivacaine injection of post-operative pain relief after tonsillectomy. Sixty-three children that classified as ASA class I and II scheduled for adenotonsillectomy and divided into three groups (every group had 21 patients). Group 1: Bupivacaine (0.5%) 2mg/kg, Group 2: Ketamine 0.5 mg/kg and Group 3: Ketamine 0.5mg/kg and Bupivacaine (0.5%) 2mg/kg was injected into tonsillar bed by the surgeon. Side effects were evaluated at 1, 4 and 24 hours after adenotonsillectomy. The correlation between the data was done by Chi-square test and a P<0.05 was considered significant. One hour after surgery, in group 3, pain score was lower than other groups (P>0.05). Besides, after 4 hours in group 3, there was no severe pain in patients and higher percent of patients (61.9%) had mild pain compared to group 2 (P>0.05) and group 1 (P<0.05). After 24 hours, higher percent of patients without pain were in group 3 compared to group 2 (P>0.05) and group 1 (P=0. 05). In conclusion, adding of Ketamine to pre-incisional Bupivacaine injection resulted in post-operative acceptable pain relief with lower side effects after adenotonsillectomy.


How to cite this article:
Choubsaz M, Mohseni G, Jorair-Ahmadi S, Sadeghi M. Comparison of the effects of adding of ketamine to pre-incisional bupivacaine injection on postoperative pain relief after tonsillectomy in children.J Rep Pharma Sci 2017;6:68-76


How to cite this URL:
Choubsaz M, Mohseni G, Jorair-Ahmadi S, Sadeghi M. Comparison of the effects of adding of ketamine to pre-incisional bupivacaine injection on postoperative pain relief after tonsillectomy in children. J Rep Pharma Sci [serial online] 2017 [cited 2018 May 20 ];6:68-76
Available from: http://www.jrpsjournal.com/article.asp?issn=2322-1232;year=2017;volume=6;issue=1;spage=68;epage=76;aulast=Choubsaz;type=0