• Users Online: 445
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
RESEARCH ARTICLE
Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 103-110

Dispersive liquid-liquid micro-extraction as a sample preparation method for clonazepam analysis in water samples and pharmaceutical preparations


Department of Chemistry, Razi University, Kermanshah, Iran

Correspondence Address:
Fahimeh Jalali
Department of Chemistry, Razi University, Kermanshah
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Dispersive liquid–liquid micro–extraction (DLLME) technique was successfully used as a sample preparation method for the determination of clonazepam in pharmaceutical preparations and water samples. In this method, a suitable mixture of methanol (disperser solvent) and chloroform (extraction solvent) was injected rapidly into a conical test tube that contained an aqueous solution of clonazepam. After centrifuging, phase separation was performed by sedimenting the fine droplets of the micro–extraction solvent on the bottom of a test tube (about 100 μL) and then the absorbance of the enriched extracted phase was determined at the absorption wavelength of clonazepam (307 nm). Some important parameters such as, the type and volume of extraction and dispersive solvents as well as the extraction time were investigated and optimized. Under the optimum conditions, the calibration graph was linear over the range of 0.95 to 18.94 μg/mL of clonazepam with a limit of detection of 0.06 μg/ml.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed619    
    Printed62    
    Emailed0    
    PDF Downloaded108    
    Comments [Add]    

Recommend this journal