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RESEARCH ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 1  |  Page : 108-115

The Effect of Satureja avromanica Maroofi Extract on Oxidative Stress Induced by Malathion in Rats


1 Medicinal Plants and Natural Products Research Center; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
2 Medicinal Plants and Natural Products Research Center; Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Neurology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Correspondence Address:
Dara Dastan
Medicinal Plants and Natural Products Research Center; Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

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Source of Support: None, Conflict of Interest: None


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Malathion is an organophosphate (OP) pesticide that has been shown to induce oxidative stress in various organisms through the generation of free radicals and alteration of the cellular antioxidant defense system independent of its anticholinesterase effects. Satureja avromanica Maroofi species has been extensively investigated as a source of natural products with potential antioxidant and antimicrobial activity. The aim of this study was to investigate the possible protective role of hydroalcoholic extract effects of S.avromanica on interlokin17 (IL17), tumor necrosis factor (TNFα), total antioxidant capacity (TAC) and lipid peroxidation (LPO) in male rats poisoned with malathion. Effective doses of malathion (150 mg/kg/day) and S.avromanica extract (1000 mg/kg/day) were administered alone or in combination for 7 days by intraperitoneal injection. At the end of the experiment, the plasma of the animals was separated. In the blood plasma, the (IL17), (TNFα), (TAC) and LPO were measured. The results showed that the S.avromanica reduced the level of IL-17 compared to the control group, but this difference was significant only compared to the malathion group. Also, receiving S.avromanica caused increased serum TAC levels in rats, which this difference was significant compared to both control and malathion groups. In addition, it was observed that S.avromanica group showed significantly decreased in LPO level, compared to the group treated with malathion. As the results display, S.avromanica plant improves the oxidative stress status and related immune system factors.


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