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RESEARCH ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 2  |  Page : 174-182

Chemical Composition, Antimicrobial and Antioxidant Activities of Crupina crupinastrum as a Medicinal Plant Growing Wild in West of Iran


1 Department of chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran
2 Medicinal Plants and Natural Products Research Center; Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Chemistry, Central Tehran Branch, I.A. University, P.O. Box 13185768, Tehran, Iran

Correspondence Address:
Dara Dastan
Medicinal Plants and Natural Products Research Center; Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

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Source of Support: None, Conflict of Interest: None


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In this study, the hydro-distilled volatile oil from the aerial parts of Crupina crupinastrum was investigated by GC-MS and GC-FID. A total of 25 compounds representing 86.4% of the volatile oil were identified. The main constituents were linoleic acid (19.1%), n-decane (12.4%) and ethyl hexadecanote (7.8%). The antioxidant activity of essential oil and methanolic extract was evaluated with DPPH radical scavenging activity. The total phenolic and flavonoids contents were also determined spectrophotometerically. The antimicrobial activity of essential oil of C. crupinastrum was examined against four gram-negative and five gram-positive bacteria. The preliminary phytochemical analysis of the methanolic extract carried out using standard procedures. The data of this study suggests that C. crupinastrum has potential for application as an antioxidant and antimicrobial agent in pharmaceutical and food industries .


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