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Year : 2020  |  Volume : 9  |  Issue : 2  |  Page : 183-188

Apoptotic effects of ginger extract (Zingiber officinale) on esophageal cancer cells ESO26: An in vitro study

1 Faculty of Nutrition and Food Industry, Pharmaceutical Science Research Center, Kermanshah, Iran
2 Department of Community Medicine, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Assistant Professor in Epidemiology, Behavioral Disease Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Diabetes Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Dr. Mehrali Rahimi
Department of Internal Medicine, Kermanshah University of Medical Science, Kermanshah.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrptps.JRPTPS_98_19

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Aim: Ginger is a natural dietary rhizome with antioxidant, anti-inflammatory, and anticarcinogenic properties. It has many medical beneficial properties such as anti-proliferation and antiapoptotic effects on cancerous esophageal cells. Materials and Methods: Esophageal cancer cells ESO26 were cultured in the presence and absence of ginger extract at various concentrations for 12, 18, and 24h. Then, the viability was determined by 3-(4,5-dimethylthiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay. Western blot analysis of caspase-3 was performed to detect apoptosis. p21, Bax, and Bcl-2 gene expression was measured using quantitative polymerase chain reaction (PCR). Data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey test. Results: The ginger extract increased the cleavage of caspase-3 in cells (P < 0.05). Results of real-time PCR have shown that ginger decreased the expression of Bcl-2 and increased Bax and p21 gene expression (P < 0.05). Conclusions: Results showed that the process of cell proliferation has been stopped. Also, this study indicated that ginger might exert a chemopreventive effect on esophageal cancer through the suppression of proliferation and the growth of tumor cells as well as the induction of apoptosis.

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